Curse II: The Bite (1989)

Curse II: The Bite is the sequel to—you guessed it—Curse. This time, our protagonist is plagued by a mutation of the worst variety: A vicious and genetically invasive snake hand! Let's back up a little. Said snake-hand-man Clark goes on a trip with his girlfriend Lisa. When they run over a land mine of live snakes (no, really—there are hundreds), one crawls into the car and bites Clark in the hand. Someone gives him an antidote, but it's the wrong one, and Clark's hand slowly begins to mutate into the creature that bit him. Not only that, but his body also slowly begins to fill with other tiny snakes. Gross. The ominous hand snake starts biting people in the face and killing them, creating a very sticky situation for Clark, and not just because of the venom. Luckily, Clark's girlfriend Lisa Snipes (played by Jill Schoelen) is hot, and she spends some time running around in the dirt in nothing but her underwear. If we had to guess, her boyfriend's hand snake is not the one she wants.