Roswell (1999-2000)

Teenage alienation is a total drag, and no one's got it worse than the kids of Roswell. They've got rocky romances, uncertain futures, and just happen to be from outer space to boot. Max, Michael, and the enchanting Isabel—played by out-of-this-world beauty Katherine Heigl—are the space cases in question, and when they aren't busy dodging government agents, they're stuck battling hormone invasions. Luckily these intergalactic whippersnappers have a human ally or two . . . and considering that their Homo sapien champions look like Shiri Appleby and Majandra Delfino, you'll be polishing your space probe faster than you can say, "I come in peace!"