Family Guy

After its initial cancellation in 2002, landmark show Family Guy was resurrected when its DVD release became the best-selling TV-based DVD of 2003. In 2005 the bumbling Griffin family, their alcoholic dog, and matricidal toddler returned to continue using their animated status to push the envelope. The characters may be cartoons, but you can always close your eyes and let the sweet voices of Mila Kunis (as hapless daughter Meg) and juggular Jennifer Tilly (as eternally knocked-up neighbor Bonnie) fuel your imagination.