Mary Steenburgen in Numb (2007)

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Matthew Perry (Friends, Studio 60 on the Sunset Strip) stars as Hudson in Numb (2007). He’s a Hollywood screenwriter coping with heavy-duty depression, and things go really off the deep end when he falls for—and fails to win over—the woman of his dreams, Sara (Lynn Collins). Hudson’s struggles are both comical and heartbreaking. Combined with nifty nudity from Holly Eglington, this film’s impact will leave you feeling anything but numb in the places where it counts most.