Debra Messing in Along Came Polly (2004)

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While honeymooning in St. Barts, anal-retentive risk analyst Reuben's (Ben Stiller) new wifey (Debra Messing) gives him the shaft up his tightly clinched seat when she gets freaky-deaky with a studly scuba instructor. Returning home buggered and broken, along comes Polly (Jennifer Aniston), a wacky waitress who made Reuben randy in junior high school. When he weighs her perky pros and cunning cons, he decides to add spice to his tasteless life by taking a calculated risk on the fun yet commitment-phobic Polly. Armed with a blind ferret, fetching face, booming body, and Looney Toon lifestyle, free-spirited Polly pumps up Reuben's peter and his outlook on life. But when Reuben’s bad-girl ex-bride returns to rekindle their rocky romance, will the now open-minded maniac return to the safety of his sick relationship, or will he stick with his sexcentric new girlfriend? With pretty Polly perched by his side, only a moron would give up taking a crack(er) at life with this bubbly breasted bird.