Christina Applegate in Samantha Who? (2007-2009)

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The ABC sitcom Samantha Who? stars Emmy-winning vavoomstress Christina Applegate as a businesswoman who gets hit by a car and wakes up with no clue who she is. A pesky case of retrograde amnesia is making her world a real headache, and as she works to put the pieces of her life together, she realizes that she doesn't like the person she was. Can comely Christina use her unfortunate brain fart as an excuse to make a brand new start?